Research
Our program is dedicated to fostering the diverse academic research interests of our residents, knowing they will soon become the future leaders of Neurology and have significant impact in our field. We are fortunate to be part of an incredibly dynamic and stimulating environment where clinical practice and research fuel each other. Clinician investigators at BWH at MGH lead some of the top-funded programs at our institutions and serve as phenomenal mentors for residents exploring burgeoning interests in clinical, translational, and basic science research. Moreover, there are rich collaborations across many first-class research institutions in the Boston area.
We work hard to help our residents find exceptional research mentors that are best suited to their interests. Every year, we have a series of conferences where our residents hear short presentations about ground-breaking work being done in the laboratories in virtually every field in neurology. We have numerous interdisciplinary conferences focused on the very latest clinical advances for a specific neurologic disease and the scientific discoveries that may soon transform the care we deliver. During quarterly meetings with house leaders and program directors, we make sure that each resident knows how to successfully navigate the landscape of available research opportunities.
All of our residents receive travel funds to attend neurologic conferences such as the AAN and other subspecialty meetings. In addition, we are very grateful to Dr. Anne Young and several former residents for generously contributing to the Beverly Mahfuz Endowed fund, which provides additional support for residents to attend conferences where they present their research.
The following resources provide more information about many of the laboratories in which our residents have explored their research interests:
The Mass General Brigham Neurology Residency Program is one of a few institutions with an R25 research training award from the NIH/NINDS. This award is designed to help residents develop the skills to begin a career in basic, translational or clinical research. We have had tremendous success with our residents receiving this grant funding, allowing them to have funding for research during residency and fellowship that ultimately supports a career development award as an independent clinician investigator.
2024 R-25 Grant Recipients
Simon Gritsch, MD, PhD
Response of IDH-mutant gliomas to mutant IDH inhibitors dissected by multiomics single-cell profiling
Mentored by Mario L. Suvà, MD, PhD
Simon’s research project leverages single-cell RNA sequencing and single-cell DNA methylation profiling in glioma patients treated with mutant IDH inhibitors to comprehensively assess the impact of these inhibitors on the glioma ecosystem. Understanding the cellular and molecular basis for the partial response of IDH mutant gliomas to IDH inhibitors will help dissect mechanisms of treatment response, predict which patients will respond, and ultimately broaden and improve such responses.
James “Jimmy” Nguyen, MD, MEd
Primary CNS vasculitis (PCNSV), a heterogeneous inflammatory vascular disorder consisting of varying initial presentations and for which there is an unmet diagnostic need given the paucity of sensitive diagnostic tests.
Mentored by Michael Levy, MD, PhD
The goal of his work is to interrogate the serum and cerebrospinal fluid for biomarkers using human cell-based assays, including microvascular endothelial cell cultures. Doing so may elucidate the pathophysiology of PCNSV and aid in its diagnostic work-up.
John Snow, MD, PhD
Establishing biomarkers of cerebral small vessel disease in COL4A1/A2-related disorders and generating a tractable in vitro disease model for mechanistic characterization and therapeutic discovery.
Mentored by Patricia Musolino, MD, PhD
The goal of John’s work is to generate a better understanding of genetic stroke syndromes that impact young adults by investigating COL4A1/A2-related disorders and the cerebral small vessel disease that frequently accompanies this diagnosis. He will use a multi-institutional cohort of patients to evaluate imaging features common to the disease and correlate these findings to serum biomarkers of neurologic disease burden. An invitro disease model will be generated using patient-derived cells to identify correlates of patient cerebral small vessel disease in a dish. This model will serve as a basis for mechanistic discovery and preclinical therapeutic screening in the near future. After residency, John will be pursuing a fellowship in Vascular Neurology.
2023 R-25 Grant Recipients
David Bargiela, MBBS, PhD
Metabolic modulation of T cell immunotherapy responses in glioblastoma multiforme
Co-mentored by Marcela Maus, MD, PhD at MGH and Matthew Vander Heiden, MD, PhD at MIT
The goal of David’s work is to understand the role of metabolism in determining immunotherapy responses in cancer. He will use cell culture and mouse models of glioblastoma multiforme combined with metabolomic techniques to evaluate the effect of targeting metabolic pathways within tumors as a strategy to improve anti-tumour immune responses. After residency, David will pursue a neuro-oncology fellowship.
Yedda Li, MD, PhD
In Vitro and Ex Vivo Precision Genome Editing for the Treatment of Adult Onset Leukoencephalopathy with Axonal Spheroids and Pigmented Glia
Yedda's co-mentors are Florian Eichler, MD and Benjamin Kleinstiver, PhD
Yedda is studying adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP), a neurodegenerative primary microgliopathy that results from mutations in the CSF1R gene. By studying ALSP pathophysiology, she hopes to delineate how bone marrow-derived immune cells and CNS-derived glial cells work together to modulate neuroinflammation. Using cutting edge precision genome editing technologies, she is also devising genome editing strategies to correct mutations in the CSF1R gene, which could provide a genetic cure for this devastating illness. After residency, Yedda looks forward to pursuing the neurogenetics fellowship at MGH/BWH.
Jessica Ye, MD, PhD
Characterizing astrocyte-oligodendrocyte precursor cell interactions and their role in immune surveillance and neurodegeneration in multiple sclerosis
Co-mentored by Francisco Quintana, PhD and Howard Weiner, MD
Using RABID-seq, a novel single cell sequencing technique capable of resolving direct cell-cell interactions developed in the Quintana laboratory, Jessica aims to study the inflammatory circuits underlying differentiation of immune-like oligodendrocyte precursor cells in mouse and human tissue, elucidating new mechanisms for glial inflammation that may be targeted in progressive MS. She will pursue a neuroimmunology fellowship at Mass General Brigham starting in 2024.
2022 R-25 Grant Recipients
Jonathan Duskin, MD
Development of a Precision Medicine Bioinformatics Tool for Cognitive Outcome Prediction after Intracerebral Hemorrhage
Mentored by Jonathan Rosand, MD & Alessandro Biffi, MD and Brandon Westover, MD, PhD
Jonathan’s co-mentors are Jonathan Rosand, MD, MSC, Alessandro Biffi, MD, and Brandon Westover, MD, PhD at MGH. The goal of Jonathan’s research is to better understand the relationship between intracerebral hemorrhage and long-term cognitive impairment. More specifically, he will be using natural language processing and machine learning to combine neuroimaging, genetic, laboratory, and clinical data into a precision medicine tool that can be used at the bedside to predict individuals’ cognitive outcomes one year after intracerebral hemorrhage. After residency, Jonathan will pursue neurocritical care fellowship.
Amr Ellaithy, MBBCh, PhD
Investigating the therapeutic mechanism of cannabidiol in Dravet Syndrome
Mentored By Stelios Smirnakis, MD, PhD
Amr's mentor is Dr. Stelios Smirnakis. Using in vivo 2-photon imaging with voltage indicators as well as spatial transcriptomics, his research aims to understand cell-type-specific effects of cannabidiol in a mouse model of Dravet syndrome. After residency, Amr will be pursuing a clinical epilepsy fellowship at BWH.
2021 R-25 Grant Recipients
Alex Bender, MD PhD
Role of sleep alterations and interictal epileptiform activity in memory impairment in patients with temporal lobe epilepsy
Alex’s co-mentors are Alice Lam, MD PhD and Sydney Cash, MD PhD. The goal of Alex’s research is to better understand cognitive impairment in epilepsy. In particular, he will be investigating the relationships between altered sleep neurophysiology, inter-ictal epileptiform abnormalities, and memory impairment. He will focus on temporal lobe epilepsy and leverage data from patients who have overnight depth electrode and scalp EEG recordings performed in our epilepsy monitoring unit. After residency, Alex will pursue an epilepsy fellowship at MGH.
Joseph Rosenthal, MD
Engineering a multimodal drug-eluting polymeric stent for therapeutic modulation of the post-stroke environment in intracranial atherosclerosis disease
Joseph's research mentor is Dr. Elazer Edelman, MD, PhD, who is a cardiac intensivist at BWH and a joint HMS/MIT professor in medical engineering and science. Working with Edelman's group to expand on existing techniques involving polymeric stent engineering for cardiac applications, Joseph's work will focus on developing a drug-eluting prototype stent capable of staged pharmaceutically-enhanced neurorecovery and neuroprotection in the acute and subacute period of ischemic infarction in intracranial atherosclerosis disease (ICAD) patients with recurrent strokes. After residency, he will pursue vascular neurology fellowship at MGH/BWH, followed by interventional neurology fellowship in the University of Texas program at the Texas Medical Center in Houston.
Douglas Wilcox, MD, PhD
The Age-Dependent Innate Immune Response to Infection at the Blood-Brain Barrier
Doug’s research mentor is Chenghua Gu, PhD at Harvard Medical School in the Department of Neurobiology. Using single-cell RNA sequencing and tissue-based assays, Doug is investigating how the blood-brain barrier serves as an immune-signaling platform in humans, and how this immune response changes throughout development to confer age-dependent differences in disease pathogenesis. After residency, Doug will pursue a research-based fellowship in Neuroimmunology and Neuroinfectious Diseases at BWH and MGH.
2020 R-25 Grant Recipient
Christine Ann Eckhardt, MD
Detection of CAR-T cell-related encephalopathy syndrome (CRES)through application of machine learning techniques to EEG
Christine’s research mentor is Brandon Westover, MD, PhD at MGH, and she is collaborating with Jorg Dietrich, MD, PhD at MGH and Henri Vaitkevicius, MD at BWH. Christine plans to utilize machine learning techniques and EEG data from patients receiving CD-19 CAR-T cell therapy, in order to predict the severity of CAR-T cell encephalopathy syndrome (CRES) and provide clinical prognostic information. After residency, she will pursue neurocritical care fellowship at BWH and MGH.
2019 R-25 Grant Recipients
Husain Danish, MD
Characterizing the tumor-immune microenvironment of brain metastases from non-small cell lung cancer (NSCLC).
Husain's research mentor is Priscilla Brastianos, MD, at Massachusetts General Hospital. Using single-cell RNA sequencing, Husain’s research will characterize the tumor-immune microenvironment of central nervous system metastases from non-small cell lung cancer (NSCLC). The goal of this work is to identify putative genetic drivers that are specific to the development of brain metastases in NSCLC. Husain will be pursuing fellowship training in Neuro-oncology beginning in 2020.
David Fischer, MD
Mapping the connectivity of a putative consciousness network in patients with acute traumatic brain injury
David's research mentors are Brian Edlow, MD, and Bruce Fischl, PhD. David will be pursuing fellowship training in neurocritical care, with a clinical emphasis on disorders of consciousness. His research focuses on using neuroimaging of brain networks to improve the diagnosis, prognostication and treatment of disorders of consciousness.
Lauren Hammer, MD, PhD
High-density mapping of deep brain stimulation cortical evoked potential networks in Parkinson’s disease
Lauren's research mentors are Sydney Cash, MD, PhD and Todd Herrington, MD, PhD. Lauren will pursue fellowship training in Movement Disorders beginning in 2020. Her research will focus on using electrophysiologic-based analysis to better understand mechanisms of successful deep brain stimulation in Parkinson’s disease.
Lauren Kett, MD, PhD
Targeting dipeptide repeat proteins in a 3D human neuronal model of C9ORF72 ALS/FTD
Lauren's research mentor is Clotilde Lagier-Tourenne, MD, PhD and her research activity will be based in the Lagier-Tourenne laboratory at the MassGeneral Institute for Neurodegenerative Disease. Lauren will be pursuing fellowship training in Neuromuscular Medicine at MGB. Her research will focus on the trafficking of toxic proteins in a novel 3D cell culture model of amyotrophic lateral sclerosis.
Sattar Khoshkhoo, MD
Single Cell Transcriptional and Genetic Profiling of Temporal Lobe Epilepsy
Sattar is hoping to study the role of somatic mutations in idiopathic adult-onset epilepsies and he will be using single cell DNA- and RNA- sequencing techniques to study that in human temporal lobe epilepsy resections. Sattar’s research mentor is Dr. Christopher A. Walsh MD, PHD at Boston Children’s Hospital and he will be pursuing a fellowship in epilepsy at MGB.
2018 R-25 Grant Recipients
Emily Ferenczi BM BCh, PhD
Characterizing neural diversity and circuit connectivity in the globus pallidus externa (GPe).
Emily’s research mentor is Bernardo Sabatini, PhD, in Harvard Medical School’s Neurobiology department. Emily’s work will harness retrograde rabies virus tracing and multi-color RNA fluorescent in situ hybridization (FISH) to characterize the molecular phenotypes of neural projections from GPe to distant brain regions. The goal of this work is to further our understanding of pathologic neural circuit mechanisms underlying basal ganglia disorders. Emily will pursuea fellowship in movement disorders beginning in 2019.
John Dickson, MD, PhD
Nuclear Pore Complex Localization and Function in Tauopathies
John’s research mentor is Bradley Hyman, MD, PhD, in the MassGeneral Institute for Neurodegenerative Disease. His research will focus on elucidating the pathogenic mechanisms of neurodegeneration, particularly focusing on nucleocytoplasmic transport through nuclear pore complexes in tauopathies. John will pursue fellowship in Cognitive Behavioral Neurology at MGH.
Andrew Stern, MD, PhD
Tau truncation, modification, and secretion in disease.
Andrew’s research mentor is Dennis Selkoe, MD, at Brigham and Women’s Hospital. Using human cerebrospinal fluid samples and stem cell-derived neurons, his research will focus on various forms of tau, a protein that folds improperly during the development of frontotemporal dementia, Alzheimer disease, progressive supranuclear palsy, and other neurodegenerative diseases.He plans to pursue clinical fellowship training in cognitive and behavioral neurology at Brigham and Women’s Hospital.
Sergio Arroyo, MD, PhD
Longitudinal single-neuron and network correlates of epileptogenesis.
Sergio's research mentors are Syd Cash, MD and Kevin Staley, MD, PhD at MGH. Using a novel extracellular probe that allows for chronic recording from single cells, Sergio aims to investigate the neuronal dynamics that lead to seizure generation. He will pursue a neurocritical care fellowship at UCSF in 2019.
2017 R-25 Grant Recipients
Robert Regenhardt, MD, PhD
Microglia in white matter repair after stroke
Robbie’s basic science research mentor is Eng Lo, PhD. Using a mouse model of stroke that targets subcortical white matter, Robert aims to investigate the role of microglia in repair processes after stroke. He is also involved in translational clinical research. He will complete a vascular neurology fellowship at Partners in 2018.
Nicolas Gonzalez Castro, MD, PhD
Characterizing oligodendroglioma and its microenvironment at single-cell resolution
Nick’s research mentors are Mario Suva, MD, PhD and Tracey Batchelor, MD, MPH at the Massachusetts General Hospital Cancer Center. His research will harness the power of single-cell RNA sequencing to better characterize the genetic diversity of high-grade gliomas and their microenviroment with a goal to better understand the biology of these tumors and identify new therapeutic targets. Nick will complete fellowship training in Neuro-Oncology at the Massachusetts General Hospital / Brigham and Women’s Hospital / Dana-Farber Cancer Institute Neuro-Oncology program.
2016 R-25 Grant Recipients
Gary Ho, MD, PhD
The role of Gaucher Disease glucocerebrosidase in the dynamics of a-synuclein multimerization
Gary’s mentor is Dennis Selkoe, MD, whose lab is part of the Ann Romney Center for Neurologic Diseases at BWH. His research will focus on the connection between Gaucher Disease and Parkinson’s disease by investigating the effects of glucocerebrosidase on multimerization of a-synuclein. Gary will complete fellowship training in movement disorders.
David Lin, MD
Investigation of the Neural Dynamics of Motor Learning Using a Brain Computer Interface
David’s research mentor is Leigh Hochberg, MD, PhD and his research will be based within the Neurotechnology Trials Unit at Massachusetts General Hospital, with close collaborations with the neuroscience and neuroengineering departments at Brown University. His research will focus on harnessing brain computer interface technology to understand the neurophysiology of motorcortical plasticity. David’s vision is to translate these insights to develop neurotechnologies to help people rehabilitate from neurologic injury. David will complete fellowship training in Neurocritical Care at Partners.
Daniel Rubin, MD, PhD
Functional Connectivity and State-Space Analysis of Physiologicand Pathologic Brain States at the Microscopic Scale in Human Cortex
Dan’s research mentors are Sydney Cash, MD, PhD and Leigh Hochberg, MD, PhD in the MGH Cortical Physiology Lab. His research will focus on understanding the changes in functional connectivity in the cortical microcircuit that underlie different forms of pathologic brain activity. Dan will complete fellowship training in Neurocritical Care at Partners.
Abby Olsen, MD, PhD
Defining the pathologic contribution of glia toalpha-synucleinopathies
Abby’s research mentor is Mel Feany, MD, PHD in the BWH Department of Neuropathology. Her project involves expressing human alpha synuclein in Drosophila neurons and glia and assessing the degree of motor impairment as well as looking for glial genes that modulate this pathology.
2015 R-25 Grant Recipients
Claire Jacobs, MD PhD
Epigenetic Regulation of Neuroplasticity in Frontotemporal Dementia
Claire’s research mentor was Prof. Steven Haggarty, PhD, who is part of the MGH Center for Human Genetic Research. She combined her clinical interests in epilepsy with her research background in chemical biology and newly acquired skills in epigenetics to investigate the epigenetics of epilepsy, with a particular focus on pediatric epilepsy syndromes. Claire completed fellowship training in Epilepsy at BWH, and has a profound interested in the process of transitioning patients from the pediatric to the adult neurology care setting.
Jennifer Kim, MD, PhD
Identifying EEG Hallmarks for Increased Seizure Risk in SAH: A Quantitative EEG Analysis
Jenn’s research mentors were Sydney Cash, MD, PhD and Brandon Westover, MD, PhD in the MGH Cortical Physiology Cash Lab. Her research focused on using quantitative EEG methods to identify EEG markers of increased seizure risk in patients who suffer acute brain injuries. Jenn pursued fellowship training in Neurocritical Care at Partners.
Richard Krolewski, MD, PhD
Understanding the role of GDF11 as a rejuvenation factor in mouse neurogenesis
His research mentor was Lee Rubin Ph.D., a member of the Harvard Stem Cell Institute, and his research was based at the Harvard Department of Stem Cell and Regenerative Biology. His research focused on understanding how the action of growth factors present in the young can be harnessed to develop therapeutics with potential to rejuvenate parts of the brain affected by neurodegenerative conditions. Rich completed fellowship training in Movement Disorders at MGH/BWH.
Khaled Moussawi, MD, PhD
Role of Neural Circuit Activity and
Plasticity in Tau Propagation
Khaled’s research mentor was Dr. Bradley Hyman, MD, PhD at MGH. Khaled pursued a fellowship in Behavioral Neurology and Neuropsychiatry.
Derek Narendra, MD, PhD
Mitochondrial proteostatic stress in parkinsonism assessed through the client repertoire of TRAP1
Derek's research mentor was Susan Lindquist, PhD at the Whitehead Institute for Biomedical Research at MIT. His research focused on the molecular pathogenesis of Parkinson’s disease. Derek pursued fellowship training in Movement Disorders.
Janice Wong, MD
Pathophysiology of neurodegenerative diseases: double-stranded RNA as a link between genomic changes and innate immunity
Janice's research mentor was Mark Albers, MD PhD at the MassGeneral Institute for Neurodegenerative Disease. Her research explored the pathophysiology of degenerative neuromuscular diseases. Janice pursued fellowship training in Neuromuscular Medicine at MGH and BWH.
